Galena scored in the 28th and 39th minutes, taking a 2-0 lead into the intermission.
Reed (4-4-3) cut the hosts' lead in half when Kenady Whitehead scored on a direct kick for the Raiders. The senior drilled a shot into the back right side of the net, just under the crossbar for the guests' lone goal.
"There was a foul right outside the box and Kenady banged it in the right top side," Reed coach Jason Saville said. "She struck it sweet. I'm not sure there's a keeper in the North that was going to make that save.
"Still, it was a bummer result for us. The girls didn't play horribly bad in the first half. We just had a hard time keeping the ball. Then in the second half, we created a lot of opportunities for ourselves. We moved the ball well and had a couple chances to tie the game. It just didn't happen."
The loss is Reed's third-straight defeat and extends its winless streak to five matches. Saville admitted there is frustration in the Raiders' camp, but he added the second half of Monday's match could be something to build on.
"There are a lot of positives to take out of the match," he said. "After dropping the last two games and being down two goals at half, we could've gone into quit mode and the girls didn't do that. They should take a lot of pride in that. The result may not have gone our way, but we're not going to lay down. Hopefully, that attitude carries forward ... if our season is going turn around, it very well could be because of how we fought in that second half today."
Monday's matchup at Galena was a make-up game. It was originally scheduled for Sept. 3 but was postponed due to poor air quality in the region at the time. The Raiders won't get much time to rest up. They host Damonte Ranch in a D-I North crossover league affair Tuesday at 6 p.m.
On the boys side, Reed couldn't get mount much of a threat at Galena Monday. The visiting Raiders were dealt a 6-0 crossover league loss.
Reed (5-7-1) was still in contention at the break, trailing 2-0, but it gave up four more scores after the break en route to getting saddled with lopsided loss.
"Galena's first goal was an own goal," Reed coach Joel Martinez said. "It brought the whole team morale down. Galena deserved it. Their shots found the back of the net. For us, we just had too many mental mistakes, breakdowns in the backfield.
"We were coming off that big win Friday at Hug. It's the same starters, the same lineup. It's frustrating for coaches and players. We have to get over this and regroup."
Reed hosts Damonte Ranch Wednesday at 7 p.m.